General Article

Circumstances of Complicated Cervical Most cancers Stay Emerging Amongst U.S. Girls

News Picture: Cases of Advanced Cervical Cancer Keep Rising Among U.S. WomenThrough Denise Mann HealthDay Reporter

FRIDAY, Aug. 19, 2022 (HealthDay Information)

New analysis issues to a conundrum with cervical most cancers: Whilst charges of early-stage illness were losing in the US ever because the human papillomavirus (HPV) vaccine was once offered, complex instances were on the upward thrust.

Which girls are being hit the toughest? The steepest uptick in complex cervical most cancers is happening in white girls who did not get the HPV shot and who were not up-to-date with their screening assessments, a discovering that means vaccination works however extra girls want to get the pictures.

Authorized via the U.S. Meals and Drug Management in 2006, the HPV shot protects towards sure lines of HPV, the most typical sexually transmitted an infection in the US. HPV has been related to a number of cancers, together with cervical most cancers, vaginal most cancers, vulvar most cancers, head and neck cancers, anal most cancers and penile most cancers. Everybody between the ages of 9 and 45 can get the HPV shot.

“In earlier analysis, we noticed a steeper decline in cervical most cancers in girls who would were eligible for the vaccine, indicating a conceivable affiliation between the vaccine and cervical most cancers price,” stated find out about creator Dr. Alex Andrea Francoeur, an obstetrician and gynecologist on the College of California, Los Angeles.

However HPV vaccination charges nonetheless lag in the back of different youth vaccinations, Francoeur famous.

For the find out about, the researchers analyzed cervical most cancers knowledge from the U.S. Most cancers Statistics program and nationwide survey findings on screening and vaccination from 2001 to 2018. Throughout this time-frame, 29,715 girls had been identified with complex cervical most cancers. Total, the speed of complex cervical most cancers greater via just about 1.5% yearly, the investigators discovered.

When cervical most cancers is complex and has unfold, it’s a lot more difficult to treatment. Best about 17% of the ones girls identified with it’ll live to tell the tale a minimum of 5 years, in comparison with 92% of ladies who’re identified with early cervical most cancers, Francoeur famous.

Black girls elderly 55 to 59 who lived within the South had been perhaps to be identified with complex cervical most cancers, however the biggest build up — a price of four.5% — was once observed amongst white girls elderly 40 to 44 from the South, the findings confirmed.

Compared with Black girls, white girls had been just about two times as most likely to not be screened for cervical most cancers in any respect or to not be screened in keeping with tips, the find out about confirmed. HPV vaccination charges had been decrease in those girls. The most important build up in instances was once for adenocarcinoma, a subtype of cervical most cancers.

“We really feel assured that HPV vaccination is general lowering general cervical most cancers occurrence within the U.S.,” Francoeur stated. “I feel we want to additional examine tips on how to display our underinsured, rural and minority populations, and proceed to teach folks at the significance of vaccination.”

The brand new find out about was once printed on-line Aug. 18 within the World Magazine of Gynecological Most cancers.

Dr. Stephanie Clean is the director of gynecologic oncology for the Mount Sinai Well being Machine in New York Town.

When the cervical most cancers vaccine referred to as Gardasil was once first rolled out, there was once gradual uptake in acceptance, she famous.

“Cervical most cancers takes years to increase, so what we’re seeing right here isn’t the entire impact of the HPV vaccine,” Clean defined.

Now not sufficient persons are being vaccinated, and those that are getting vaccinated don’t seem to be younger sufficient after they do obtain the pictures, she stated. Preferably, folks will have to be vaccinated sooner than they’re ever uncovered to HPV, which happens maximum often within the past due teenagers and early 20s.




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“Extra vaccinations of all genders and at more youthful ages will have to opposite this development,” Clean stated.

Alternative ways to show issues round come with systems to teach folks in regards to the HPV vaccine and to make sure that programs are in position so folks from under-resourced and under-insured communities have get right of entry to to vaccination and cervical most cancers screening systems, she stated.

Additional info

The U.S. Facilities for Illness Regulate and Prevention has extra at the HPV vaccine.

SOURCES: Alex Andrea Francoeur, MD, obstetrician/gynecologist, College of California, Los Angeles; Stephanie Clean, MD, director, gynecologic oncology, Mount Sinai Well being Machine, New York Town; World Magazine of Gynecological Most cancers, Aug. 18, 2022, on-line

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Being pregnant Can Be Nervous Time for Ladies With Epilepsy

News Picture: Pregnancy Can Be Anxious Time for Women With Epilepsy

THURSDAY, Aug. 18, 2022 (HealthDay Information)

Pregnant ladies with epilepsy fight anxiousness and despair extra incessantly than their friends who are not pregnant or wouldn’t have epilepsy, a brand new find out about unearths.

“The excellent news is we didn’t in finding that pregnant ladies with epilepsy had been to any extent further prone to have episodes of main despair than the opposite two teams,” mentioned find out about writer Dr. Kimford Meador, a professor of neurology at Stanford College College of Drugs, and a fellow of the American Academy of Neurology.

“On the other hand, those effects underscore the significance of steadily screening pregnant ladies with epilepsy for any indicators of despair or anxiousness and offering efficient remedy,” he mentioned.

The brand new find out about incorporated 331 ladies who had been pregnant and had epilepsy, 102 pregnant ladies with out epilepsy, and 102 ladies who had epilepsy however weren’t pregnant.

Researchers met with the pregnant ladies throughout each and every trimester, close to their supply and each 3 months till 9 months later on, screening them for despair, anxiousness and different psychiatric issues. The researchers met with the ladies who weren’t pregnant at related time issues.

They discovered that pregnant ladies with epilepsy had been much more likely to have signs of despair throughout being pregnant than the ladies with epilepsy who weren’t pregnant. After giving delivery, they had been much more likely to have despair signs than each different teams.

All through being pregnant, the ladies with epilepsy had a mean ranking of seven on a take a look at of despair signs, in comparison to a mean ranking of 6 for pregnant ladies with out epilepsy. Ladies who weren’t pregnant however had epilepsy had a mean ranking of five. A ranking of 10 or upper presentations delicate temper disturbance.

In comparison to each different teams, pregnant ladies with epilepsy additionally had extra signs of tension. On a take a look at of tension signs, they scored a 6, whilst the opposite teams scored a 5. A ranking of 8 or extra signifies delicate anxiousness.

The investigators discovered no proof of main despair, however they did establish chance components. They incorporated multiple seizure previously 3 months; taking multiple epilepsy drug; having an unplanned being pregnant, and a historical past of temper issues.

The findings had been printed Aug. 17 in Neurology.

“Despair is incessantly under-recognized in other people with epilepsy, but we all know that efficient control of despair can enhance other people’s high quality of lifestyles and their general results for epilepsy remedy, so ladies with epilepsy must be monitored intently throughout being pregnant and evaluated when they’re excited about making plans a being pregnant,” Meador mentioned in a magazine information liberate.

The researchers famous that the find out about had a number of boundaries. It didn’t come with sufficient ladies to totally overview the have an effect on of particular person epilepsy medicines on signs of despair and anxiousness. As well as, they mentioned members won’t have recalled signs that passed off between find out about visits.

Additional info

The Epilepsy Basis has knowledge on being pregnant making plans with epilepsy.

SOURCE: Neurology, information liberate, Aug. 17, 2022

Through Cara Murez HealthDay Reporter

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Exchange to Prognosis of Gestational Diabetes Helped Ladies

News Picture: Change to Diagnosis of Gestational Diabetes Helped WomenBy way of Amy Norton HealthDay Reporter

THURSDAY, Aug. 18, 2022 (HealthDay Information)

The use of a decrease threshold to diagnose pregnancy-related diabetes does no longer appear to scale back the danger of getting a large child, on reasonable — however some ladies do get advantages, a brand new medical trial suggests.

Gestational diabetes is identified when a pregnant lady’s blood sugar ranges are abnormally prime. The situation could have penalties for mothers and young children, a prime one being fetal overgrowth. That leads to a large child and a hard supply that may injure the baby or mom, and lift the percentages of a Cesarean segment supply. As well as, some babies are born with low blood sugar or respiring issues that require remedy.

For ladies, in the meantime, gestational diabetes raises the danger of preeclampsia — a doubtlessly unhealthy situation the place blood force rises and protein accumulates within the urine.

However whilst gestational diabetes is repeatedly identified, professionals are nonetheless debating precisely how you can outline it, stated Dr. Michael Greene, a professor emeritus of obstetrics and gynecology at Harvard Clinical College, in Boston.

“The issue has been amassing the proof on the place to attract the road,” stated Greene, who wrote an article revealed with the brand new learn about within the Aug. 18 factor of the New England Magazine of Medication.

Again in 2010, the American Diabetes Affiliation and the World Affiliation of the Diabetes and Being pregnant Learn about Teams (IADPSG) diminished their beneficial blood sugar thresholds for diagnosing gestational diabetes.

That was once in response to a big global learn about that discovered the hazards of adverse being pregnant results steadily rose with blood sugar ranges. There was once no transparent “inflection level,” Greene defined, which may be used as a cutoff for diagnosing gestational diabetes.

So, the professional consensus was once to decrease the blood-sugar threshold for diagnosing the situation, within the hopes it would save you extra being pregnant headaches.

Within the new trial, researchers in New Zealand examined the affect of the ones decrease thresholds, as opposed to increased ones which can be nonetheless utilized in that nation.

And so they discovered that, total, ladies identified with gestational diabetes in keeping with the decrease threshold have been no much less prone to have a big new child, as opposed to the ones identified in response to the upper thresholds.

However there have been advantages when the researchers centered at the subgroup of ladies whose blood sugar ranges fell in between the upper and decrease thresholds — which means they do not have been identified with gestational diabetes in response to the upper cutoff.

Amongst the ones ladies, remedy for gestational diabetes did decrease the danger of getting a big new child, in addition to the danger of preeclampsia.

“The well being variations we did see… have been pushed by way of the 9% of ladies with ‘milder’ gestational diabetes, whose [blood sugar] effects fell in between the upper and decrease thresholds,” defined lead researcher Dr. Caroline Crowther, of the College of Auckland.

She stated the discovering helps the usage of the decrease cutoff — although that can imply extra pregnant ladies being handled for diabetes. That generally manner nutrition adjustments, bodily process and often doing finger-sticks to test blood sugar ranges; some ladies wish to take insulin or the oral drugs metformin.

“Use of the decrease [blood sugar] threshold will imply extra ladies shall be identified with gestational diabetes, and that can build up well being provider usage,” Crowther stated. “However for the ladies with milder gestational diabetes so detected and handled, the learn about suggests necessary well being advantages.”




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The learn about concerned simply over 4,000 pregnant ladies who have been being evaluated for gestational diabetes. Part have been randomly assigned to a higher-threshold team, the place the situation was once identified in keeping with suggestions utilized in New Zealand. The opposite part have been assigned to a lower-threshold team, the usage of the blood sugar cutoffs beneficial by way of the IADPSG.

As anticipated, the decrease cutoffs resulted in additional ladies being identified with gestational diabetes: 15% as opposed to 6%. Just below 9% of newborns in each teams have been massive for gestational age — above the ninetieth percentile for young children born at that week of being pregnant.

Then, the researchers interested by that team of ladies between the 2 thresholds, who might be thought to be to have gentle gestational diabetes. Amongst the ones within the lower-threshold team — who have been identified and handled for the situation — 6% had a big new child. That in comparison with 18% within the higher-threshold team, who went untreated.

General Article

COVID Vaccine Secure for Pregnant Ladies: Find out about

News Picture: COVID Vaccine Safe for Pregnant Women: Study

MONDAY, Aug. 15, 2022 (HealthDay Information)

The preferred COVID-19 vaccines are secure to make use of in being pregnant, a big, new Canadian find out about has concluded.

About 4% of pregnant ladies given an mRNA vaccine had a vital well being match inside of per week in their first dose, and about 7% did after dose two, in line with knowledge accumulated from greater than 191,000 Canadian ladies.

Via comparability, 3% of unvaccinated pregnant ladies reported equivalent important well being occasions, which have been outlined as an sickness that made the individual leave out paintings or faculty, required a scientific session, or averted them from collaborating in common day by day actions.

The most typical important well being occasions after dose two in pregnant ladies have been a basic feeling of being sick, headache or migraine, and respiration tract an infection.

Amongst a keep an eye on staff of vaccinated however no longer pregnant other folks, about 6% reported a well being match after the primary dose and 11% after the second one, in line with the record revealed on-line Aug. 11 in The Lancet Infectious Sicknesses.

The find out about, which used to be led by way of Manish Sadarangani, of the Vaccine Analysis Middle at BC Kids’s Health center Analysis Institute in Vancouver, is likely one of the first to match vaccine negative effects between vaccinated pregnant ladies, unvaccinated pregnant ladies, and a 3rd staff that used to be vaccinated however no longer pregnant.

Severe well being occasions — outlined as requiring an emergency division seek advice from or hospitalization — have been uncommon in all teams (lower than 1%).

Miscarriage or stillbirth used to be probably the most steadily reported adversarial being pregnant end result, however there used to be no important distinction between the charges of the ones in vaccinated and unvaccinated ladies, the find out about authors reported in a magazine information unlock.

About 2% of unvaccinated pregnant ladies and 1.5% of vaccinated pregnant ladies skilled a miscarriage or stillbirth inside of seven days after dose certainly one of any mRNA vaccine.

The findings “are in step with and upload to the rising frame of proof that COVID-19 mRNA vaccines are secure all the way through being pregnant,” claimed a remark that accompanied the brand new find out about.

Additional information

The U.S. Facilities for Illness Keep an eye on and Prevention has extra about COVID-19 vaccines.

SOURCE: The Lancet Infectious Sicknesses, information unlock, Aug. 11, 2022

Via Dennis Thompson HealthDay Reporter

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Vegetarian Girls at Upper Odds for Hip Fracture

Newest Girls’s Well being Information

News Picture: Vegetarian Women at Higher Odds for Hip FractureBy means of Denise Mann HealthDay Reporter

THURSDAY, Aug. 11, 2022 (HealthDay Information)

Report numbers of persons are turning to plant-based diets to profit from the numerous well being advantages they provide, however this will come on the expense in their bones, a brand new learn about suggests.

Precisely what did researchers to find? Center-aged girls who by no means consume meat is also much more likely to damage a hip than girls who frequently devour meat and/or fish.

Extra learn about is had to perceive why vegetarians appear to be at better chance for hip fractures, however researchers suspect that low frame mass index (BMI) and nutrient shortfalls play a task.

“While a decrease BMI is really useful for plenty of well being stipulations, being underweight can result in inadequate fats mass, and deficient bone and muscle well being, which is able to each and every build up hip fracture chance,” stated learn about creator James Webster. He’s a doctoral researcher from the Faculty of Meals Science and Diet on the College of Leeds in England. BMI is an estimate of frame fats in accordance with weight and peak. The common BMI of vegetarians within the learn about was once reasonably less than that of meat eaters.

“Folks with much less fats mass have much less cushioning throughout falls, and falls account for 90% of hip fractures,” he defined.

Meat and fish also are superb assets of a number of vitamins for bone well being, together with protein, diet B12 and diet D.

“It’s conceivable to get these kind of vitamins from plant assets, eggs and dairy merchandise, [but] earlier research have discovered decrease intakes of those vitamins in vegetarians,” Webster stated. Within the learn about, vegetarians had decrease intakes of protein and diet B12 than other people who ate meat 5 or extra instances each and every week.

Within the learn about, researchers checked out charges of hip fractures in over 26,000 girls elderly 35 to 69 who ate meat not more than 4 instances every week (occasional meat eaters); pescatarians who ate fish however no longer meat; vegetarians; and common meat-eaters who ate up meat a minimum of 5 instances every week. The ladies crammed out meals frequency questionnaires, and those had been when put next in opposition to health center information to look who suffered a hip fracture. Throughout about twenty years of follow-up, there have been 822 hip fractures.

Vegetarians had been the one team who had an increased chance of hip fracture as soon as researchers managed for different components recognized to extend this chance, together with smoking standing and bodily job stage.

The findings had been revealed on-line Aug. 11 within the magazine BMC Drugs.

There are steps that vegetarians can take to raised give protection to their bones whilst taking part in the center and different well being advantages of a plant-based vitamin, Webster stated. This begins with keeping up a wholesome weight, which will increase the chance of wholesome bones and muscular tissues, and is helping to scale back hip fracture chance.

Consuming loads of vegetables and fruit, nuts, legumes, beans and entire grains supplies many of the vitamins wanted for bone well being and fracture prevention, he added.

Imagine fortified meals and dietary supplements, too, he prompt. “Consuming meals fortified with key vitamins or taking dietary dietary supplements too can lend a hand keep away from dietary deficiencies, in particular for diet B12 and omega-3 fatty acids, which might be tricky to get from plant meals at once,” Webster stated.

Fending off smoking and over the top alcohol intake, whilst getting common workout, too can lend a hand stay bones robust. “Resistance workout, the place you carry or pull in opposition to resistance, equivalent to weight coaching, is also in particular really useful via expanding bone and muscle energy,” Webster stated.




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New Austrian analysis revealed ultimate week backs up this recommendation: Vegans who carry weights or do energy coaching have more potent bones than vegans who simplest do different types of workout, equivalent to cycling or swimming.

Dietitians no longer concerned with the brand new learn about identified that constructing robust and wholesome bones comes to extra than simply getting sufficient calcium.

Magnesium, potassium, boron, zinc, copper, manganese, diet D and diet K2 also are vital, stated Robin Foroutan, a New York dietitian.

“Protein is seriously vital to constructing a powerful and versatile bone matrix,” she stated. “Vegetarian assets of protein is also tougher to digest and take in for some other folks, which makes the protein much less bioavailable.”

That specialize in fine quality assets of vegetarian protein, in addition to darkish leafy

General Article

Males Extra Susceptible to Most cancers Than Girls, However Why?

Image: Men More Prone to Cancer Than Women, But Why?By means of Denise Mann HealthDay Reporter

Males are recognized to be much more likely to broaden most cancers than girls, and a brand new find out about means that that is in large part because of biologic variations between the sexes.

“After controlling for components like smoking, alcohol use, vitamin, bodily task and commonplace scientific stipulations [that increase cancer risk], the intercourse bias remained for many cancers,” stated find out about creator Sarah Jackson, a analysis fellow on the Nationwide Most cancers Institute’s Department of Most cancers Epidemiology and Genetics.

Precisely which organic variations are riding those disparities is not absolutely understood but.

“We would… love to discover the contribution of intercourse hormones and genetics to most cancers occurrence in long run analysis,” she stated.

For the find out about, researchers checked out variations in possibility for 21 most cancers websites amongst 171,000 males and 123,000 girls between 50 and 71 years of age who had been enrolled in a vitamin and well being find out about from 1995 to 2011.

Throughout that point, 17,951 new cancers had been identified in males, and eight,742 had been present in girls.

Males had upper dangers for many cancers, with the best distinction in possibility noticed for cancers of the esophagus (10.8 instances upper); larynx and bladder (every 3.5 instances upper); in addition to gastric cardia, a kind of abdomen most cancers (3.three times upper).

Males handiest had decrease charges of thyroid and gallbladder cancers, the find out about confirmed.

Jackson stated males also are much more likely to die of most cancers than girls.

Possibility components equivalent to smoking, alcohol, vitamin and underlying well being problems accounted just for a small fraction of the adaptation in males’s and ladies’s most cancers charges. For instance, smoking, vitamin and stipulations like diabetes that may build up the danger for some cancers defined handiest 20% of the male bias in bladder most cancers. Males are greater than 3 times as prone to broaden bladder most cancers than girls, Jackson stated.

The find out about used to be printed Aug. 8 within the magazine Most cancers. Going ahead, researchers plan to have a look at intercourse variations in most cancers charges amongst racial and ethnic teams.

In a piece of writing that accompanied the findings, Jangqin Luo stated extra analysis is had to perceive why males are much more likely than girls to broaden many cancers.

“Intercourse disparities had been actively studied up to now a long time, and the broadcast analysis findings have deepened our figuring out, [but] intercourse distinction in most cancers continues to be an ongoing quest,” stated Luo, an affiliate professor of surgical operation on the Washington College College of Medication in St Louis.

Working out those disparities will pave the best way towards higher prevention and remedy insurance policies, she stated.

Dr. Otis Brawley, a professor of oncology at Johns Hopkins College College of Medication in Baltimore, agreed that it is time to pay extra consideration to intercourse variations in most cancers charges.

“The extra cells you’ve got, the much more likely certainly one of them is to transform malignant, and males have a tendency to be larger than girls,” stated Brawley, who reviewed the findings.

A few of these variations is also associated with hormones. The male intercourse hormone testosterone would possibly advertise the expansion of a few cancers, and the feminine intercourse hormone estrogen would possibly be offering coverage in opposition to others.

“Once we do epidemiological research and remedy research, it is very important have a look at males as opposed to girls,” Brawley stated.

Consuming a nutritious diet, keeping up a typical weight, no longer smoking or ingesting alcohol in extra, and different wholesome behaviors are nonetheless a very powerful a part of a most cancers prevention technique for women and men, he stated.

SOURCES: Sarah Jackson, PhD, MPH, analysis fellow, Nationwide Most cancers Institute, Rockville, Md.; Jangqin Luo, PhD, affiliate professor, surgical operation, Department of Public Well being Sciences, Washington College College of Medication, St. Louis; Otis Brawley, MD, professor, oncology, Johns Hopkins College College of Medication, Baltimore; Most cancers, Aug. 8, 2022

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Lung Most cancers Can Diminish Sexual Well being for Girls

News Picture: Lung Cancer Can Diminish Sexual Health for Women

THURSDAY, Aug 11, 2022 (HealthDay Information)

Sexual disorder is a commonplace facet impact amongst ladies with lung most cancers, a brand new find out about reveals.

“The SHAWL [Sexual Health Assessment in Women with Lung Cancer] find out about is set bringing ladies’s sexuality to the leading edge of medical discussions as a result of it’s been considerably understudied,” mentioned researcher Dr. Narjust Florez (Duma), affiliate director for the Most cancers Care Fairness Program at Dana-Farber Most cancers Institute in Boston. “When evaluating the tips sooner than lung most cancers analysis and after lung most cancers analysis, the variation is staggering. Lung most cancers considerably impacts the sexual well being of those ladies.”

For the find out about, individuals had been requested about sexual job sooner than lung most cancers and all the way through the 30 days sooner than they finished the survey.

In all, 249 ladies finished the survey. Inside the month, 53% had sexual job with themselves or any person else; 77% had little to little interest in intercourse; and 67% hardly ever or by no means sought after to have intercourse.

The commonest causes for dissatisfaction with their intercourse lifestyles incorporated fatigue (40%); feeling unhappy or unsatisfied (28%); problems with their companions (22%); and shortness of breath (15%), the find out about discovered.

Marked variations had been famous in reduced sexual need (15% sooner than analysis as opposed to 31% after); and vaginal ache or discomfort (13% sooner than analysis and 43% after).

Of 127 ladies who reported sexual job within the previous month, 59% had problems with vaginal dryness and 26% had vaginal ache or discomfort.

“Sexual disorder is prevalent in ladies with lung most cancers, and we wish to understand that sexual well being is said to high quality of lifestyles,” Florez mentioned in a Dana-Farber information unlock.

She mentioned sexual well being must be regarded as as a part of thoracic most cancers remedy and extra analysis is vital to broaden adapted interventions for lung most cancers sufferers. The ones whose sexual well being is addressed have higher high quality of lifestyles, higher ache keep watch over and higher relationships with their companions and their well being care crew, Florez mentioned.

The findings had been slated for presentation Tuesday at a gathering of the World Affiliation for the Find out about of Lung Most cancers in Vienna. Findings offered at scientific conferences are regarded as initial till printed in a peer-reviewed magazine.

Additional information

Be informed extra about lung most cancers from the American Most cancers Society.

SOURCE: Dana-Farber Most cancers Institute, Boston, information unlock, Aug. 9, 2022

By means of Steven Reinberg HealthDay Reporter

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QUESTION


Lung most cancers is a illness by which lung cells develop abnormally in an out of control method.
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